# Rypamycin - research papers
**URL:** https://talk.gridnet.org/t/rypamycin-research-papers/91
**Category:** Bio Hacking
**Created:** [June 26, 2022, 4:42pm UTC](https://talk.gridnet.org/t/rypamycin-research-papers/91 "2022-06-26T16:42:14Z")
**Posts on this page:** 5
**Page:** 1
### Author:  [@Major](https://talk.gridnet.org/u/Major)
#### Post date: [June 26, 2022, 4:42pm UTC](https://talk.gridnet.org/t/rypamycin-research-papers/91/1 "2022-06-26T16:42:14Z")
The current Holy Grail as far as I can tell - Rypamycin.
Any news, research papers, conversations in regards to dosing are invited to go right here.
> **[Rapamycin extends life- and health span because it slows aging - PubMed](https://pubmed.ncbi.nlm.nih.gov/23934728/)**
>
> Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death...
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### Author:  [@Major](https://talk.gridnet.org/u/Major)
#### Post date: [June 26, 2022, 4:47pm UTC](https://talk.gridnet.org/t/rypamycin-research-papers/91/2 "2022-06-26T16:47:43Z")
[https://www.science.org/doi/10.1126/scitranslmed.aan4296](https://www.science.org/doi/10.1126/scitranslmed.aan4296)
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### Author:  [@Alpacalypse](https://talk.gridnet.org/u/Alpacalypse)
#### Post date: [June 26, 2022, 8:28pm UTC](https://talk.gridnet.org/t/rypamycin-research-papers/91/3 "2022-06-26T20:28:57Z")
I dunno how reliable is wikipedia article regarding rapamycin:
> **[Sirolimus](https://en.wikipedia.org/wiki/Sirolimus)**
>
> Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mechanistic target of rapamycin kinase (mTOR) inhibitor It is produc...
But 3%-20% chance to get skin cancer and/or other side effects is kinda scary. Any info regarding side effect mitigation?
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### Author:  [@Major](https://talk.gridnet.org/u/Major)
#### Post date: [June 30, 2022, 10:34am UTC](https://talk.gridnet.org/t/rypamycin-research-papers/91/4 "2022-06-30T10:34:34Z")
Doesn’t the very same article (on Wikipedia) state that:
> In studies, the skin cancer risk under sirolimus was lower than under other immunosuppressants such as [azathioprine](https://en.wikipedia.org/wiki/Azathioprine) and [calcineurin inhibitors](https://en.wikipedia.org/wiki/Calcineurin_inhibitor), **and lower than under [placebo]**([Placebo - Wikipedia](https://en.wikipedia.org/wiki/Placebo)).[[1]](https://en.wikipedia.org/wiki/Sirolimus#cite_note-Rapamune_FDA_label-1)[[44]](https://en.wikipedia.org/wiki/Sirolimus#cite_note-44)
🤔 Also, keep in mind that life-extension dosages tend to be way smaller than those used while treating transplantation patients. Also , one does not take such a cocktail on daily-basis, but say once… maybe twice… a week; at least that is what I do.
I’m gonna contact a buddy of mine regarding the skin-cancer topic, anyway.
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### Author:  [@Alpacalypse](https://talk.gridnet.org/u/Alpacalypse)
#### Post date: [July 1, 2022, 8:11am UTC](https://talk.gridnet.org/t/rypamycin-research-papers/91/5 "2022-07-01T08:11:18Z")
Fair enough, I kinda missed that in the wiki article, thanks. Side effects list is kinda scary tho, hence my caution. I am all up for chemical support of biological functions, gotta look for sources of these delicious cocktails in Poland.
On the side note, a while ago I’ve seen an article regarding modified artemisinin (some compound added to support migration into cells) to be used as cancer treatment, but now i can’t find anything besides some alternative medicine websites. Do you know if it was a sham or was it legit?